Abstract The promise of precision medicine has been limited by the pervasive resistance to many targeted therapies for cancer.Inferring the timing (i.e., pre-existing or acquired) and mechanism (i.e., drug-induced) of such resistance is crucial for designing effective new att nighthawk hotspot therapeutics.This paper studies cetuximab resistance in
Efficacy of heel lifts versus calf muscle eccentric exercise for mid-portion Achilles tendinopathy (the HEALTHY trial): study protocol for a randomised trial
Abstract Background Mid-portion Achilles tendinopathy is a common musculoskeletal condition characterised by degeneration of the Achilles tendon, which causes pain and disability.Multiple non-surgical treatments have been advocated for this condition including calf muscle eccentric exercise and in-shoe heel lifts.Although adherence is challenging,
Dynamics Analysis of Locomotive Transmission System based on Romax
Taking a 15-eg1053cl locomotive traction transmission system as research object,the relatively complete transmission system model is built considering shaft deformation,flexible body,motor and wheel rail friction factors.From the static,modal analysis and dynamics analysis of the model,finding the causes of noise and vibration are the transmission